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Učinci kokaina na mozak mogu biti prilično značajni. Receptori za neurotransmiter koji se naziva glutamat i njegova oslobođena količina značajno se mijenjaju kod ljudi koji dugo upotrebljavaju kokain. Smatra se da su ove promjene povezane s adiktivnim svojstvima droge.[118] Persistent consumers may get rid of their urge for food and can worki